Вестник БГУ. Медицина и фармация
Библиографическое описание:
ПРИМЕНЕНИЕ КОФЕИНА В НЕОНАТАЛЬНОЙ ПРАКТИКЕ // Вестник БГУ. Медицина и фармация. - 2025. №4. . - С. 16-21.
Заглавие:
ПРИМЕНЕНИЕ КОФЕИНА В НЕОНАТАЛЬНОЙ ПРАКТИКЕ
Финансирование:
Коды:
Аннотация:
Кофеин является одним из наиболее часто назначаемых препаратов в совре- менной неонатологии. Его включение в международные и национальные руководства основано на убедительной доказательной базе, подтверждающей значительную пользу. Существуют различные подходы к терапии и заметные расхождения в вопросах времени начала, дозировки и продолжительности лечения. Проведен обзор литературы, задачами которого являются: 1) определить доказательные обоснования использования кофеина в неонатальной практике, преимущества его применения и целевые группы пациентов; 2) провести анализ альтернативных источников, выявляющих побочные эффекты, противопоказания и опасности применения кофеина у новорожденных; 3) определить место кофеина в неонатальной практике на современном этапе.
Ключевые слова:
кофеин, недоношенные новорожденные, современная неонатоло- гия, фармакотерапия.
Список литературы:
Schmidt B., Anderson P., Doyle L., Dewey D., Grunau R. E., Asztalos E. The caffeine for apnea of prematurity (CAP) trial: preliminary outcomes at 5 years. Pediatric Research. 2011; 70; 55: 24.
Aranda J. V, Gorman W., Bergsteinsson H., Gunn T. Efficacy of caffeine in treatment of apnea in the low-birth-weight infant. J Pediatr. 1977; 90: 467–72.
Saroha V., Patel R. M. Caffeine for preterm infants: Fixed standard dose, adjustments for age or high dose? Semin Fetal Neonatal Med. 2020; 25(6): 101178.
Steer P., Flenady V., Shearman A., Charles B., Gray P. H., Henderson-Smart D., Bury G., Fraser S., Hegarty J., Rogers Y., Reid S., Horton L., Charlton M., Jacklin R., Walsh A. Caffeine Collaborative Study Group Steering Group. High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2004; 89(6): F499–503.
Wan L., Huang L., Chen P. Caffeine citrate maintenance doses effect on extubation and apnea postventilation in preterm infants. Pediatr Pulmonol. 2020; 55(10): 2635–2640.
Bruschettini M., Brattström P., Russo C., Onland W., Davis P. G., Soll R. Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity. Cochrane Database Syst Rev. 2023; 11; 4(4): CD013873.
Kovács K., Nagy R., Andréka L., Teutsch B., Szabó M., Varga P., Hegyi P., Hársfalvi P., Ács N., Harmath Á., Nádor C., Gasparics Á. The effect of an additional pre-extubational loading dose of caffeine citrate on mechanically ventilated preterm infants (NEOKOFF trial): Study protocol for a multicenter randomized clinical trial. PLoS One. 2025; 13; 20(1): e0315856.
Moschino L., Zivanovic S., Hartley C., Trevisanuto D., Baraldi E., Roehr C. C. Caffeine in preterm infants: where are we in 2020? ERJ Open Res. 2020; 2; 6(1): 00330–2019.
Ma J., Chen L., Mu K., Tang S., Shi Y. Early caffeine therapy decreases bronchopulmonary dysplasia but might increase mortality in preterm infants? a systematic review and meta-analysis. Front Pediatr. 2025; 21; 13: 1528054.
Heise J., Schmitz T., Bührer C., Endesfelder S. Protective Effects of Early Caffeine Administration in Hyperoxia-Induced Neurotoxicity in the Juvenile Rat. Antioxidants (Basel). 2023; 28; 12(2): 295.
Hamad AKS. Caffeine and Arrhythmias: A Critical Analysis of Cardiovascular Responses and Arrhythmia Susceptibility. J Saudi Heart Assoc. 2024; 16; 36(4): 335-348.
Lodha A., Entz R., Synnes A., Creighton D., Yusuf K., Lapointe A., Yang J., Shah P. S; investigators of the Canadian Neonatal Network (CNN) and the Canadian Neonatal Follow-up Network (CNFUN). Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants. Pediatrics. 2019; 143(1): e20181348.
Kilpatrick R., Davis J. M., Aranda J. V. Caffeine: how early is too early? Pediatr Res. 2024; 96(3): 555–557.
Amaro C. M., Bello J. A., Jain D., Ramnath A., D'Ugard C., Vanbuskirk S., Bancalari E., Claure N. Early caffeine and weaning from mechanical ventilation in preterm infants: A randomized, placebo-controlled trial. The Journal of pediatrics. 2018; 196: 52–57.
Rodgers A., Singh C. Specialist neonatal respiratory care for babies born preterm (NICE guideline 124): a review. Arch Dis Child Educ Pract Ed. 2020; 105(6): 355–357.
Chavez Valdez R., Ahlawat R., Wills-Karp M., Nathan A., Ezell T., Gauda E. B. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Pediatr. 2011; 158(1): 57–64, 64.e1.
Eichenwald E. C; Committee on Fetus and Newborn, American Academy of Pediatrics. Apneaof Prematurity. Pediatrics. 2016; 137(1).
Aranda J. V, Gorman W., Bergsteinsson H., Gunn T. Efficacy of caffeine in treatment of apnea in the low-birth-weight infant. J Pediatr. 1977; 90: 467–72.
Saroha V., Patel R. M. Caffeine for preterm infants: Fixed standard dose, adjustments for age or high dose? Semin Fetal Neonatal Med. 2020; 25(6): 101178.
Steer P., Flenady V., Shearman A., Charles B., Gray P. H., Henderson-Smart D., Bury G., Fraser S., Hegarty J., Rogers Y., Reid S., Horton L., Charlton M., Jacklin R., Walsh A. Caffeine Collaborative Study Group Steering Group. High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2004; 89(6): F499–503.
Wan L., Huang L., Chen P. Caffeine citrate maintenance doses effect on extubation and apnea postventilation in preterm infants. Pediatr Pulmonol. 2020; 55(10): 2635–2640.
Bruschettini M., Brattström P., Russo C., Onland W., Davis P. G., Soll R. Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity. Cochrane Database Syst Rev. 2023; 11; 4(4): CD013873.
Kovács K., Nagy R., Andréka L., Teutsch B., Szabó M., Varga P., Hegyi P., Hársfalvi P., Ács N., Harmath Á., Nádor C., Gasparics Á. The effect of an additional pre-extubational loading dose of caffeine citrate on mechanically ventilated preterm infants (NEOKOFF trial): Study protocol for a multicenter randomized clinical trial. PLoS One. 2025; 13; 20(1): e0315856.
Moschino L., Zivanovic S., Hartley C., Trevisanuto D., Baraldi E., Roehr C. C. Caffeine in preterm infants: where are we in 2020? ERJ Open Res. 2020; 2; 6(1): 00330–2019.
Ma J., Chen L., Mu K., Tang S., Shi Y. Early caffeine therapy decreases bronchopulmonary dysplasia but might increase mortality in preterm infants? a systematic review and meta-analysis. Front Pediatr. 2025; 21; 13: 1528054.
Heise J., Schmitz T., Bührer C., Endesfelder S. Protective Effects of Early Caffeine Administration in Hyperoxia-Induced Neurotoxicity in the Juvenile Rat. Antioxidants (Basel). 2023; 28; 12(2): 295.
Hamad AKS. Caffeine and Arrhythmias: A Critical Analysis of Cardiovascular Responses and Arrhythmia Susceptibility. J Saudi Heart Assoc. 2024; 16; 36(4): 335-348.
Lodha A., Entz R., Synnes A., Creighton D., Yusuf K., Lapointe A., Yang J., Shah P. S; investigators of the Canadian Neonatal Network (CNN) and the Canadian Neonatal Follow-up Network (CNFUN). Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants. Pediatrics. 2019; 143(1): e20181348.
Kilpatrick R., Davis J. M., Aranda J. V. Caffeine: how early is too early? Pediatr Res. 2024; 96(3): 555–557.
Amaro C. M., Bello J. A., Jain D., Ramnath A., D'Ugard C., Vanbuskirk S., Bancalari E., Claure N. Early caffeine and weaning from mechanical ventilation in preterm infants: A randomized, placebo-controlled trial. The Journal of pediatrics. 2018; 196: 52–57.
Rodgers A., Singh C. Specialist neonatal respiratory care for babies born preterm (NICE guideline 124): a review. Arch Dis Child Educ Pract Ed. 2020; 105(6): 355–357.
Chavez Valdez R., Ahlawat R., Wills-Karp M., Nathan A., Ezell T., Gauda E. B. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Pediatr. 2011; 158(1): 57–64, 64.e1.
Eichenwald E. C; Committee on Fetus and Newborn, American Academy of Pediatrics. Apneaof Prematurity. Pediatrics. 2016; 137(1).
Статья.pdf