, , , Antiexudative Activity of Calendula Officinalis in case of Experimental Chemical Burns of the Esophagus Acetic ACID // BSU bulletin. Medicine and pharmacy. - 2017. №3. . - С. 38-46.

Antiexudative Activity of Calendula Officinalis in case of Experimental Chemical Burns of the Esophagus Acetic ACID

UDK: 615.322

The article presents the data of electrophysiological condition of the esophaguswalls in cases of experimental chemical burns with acetic acid. The experiment has been carried out on 62 lines of rats Vistar. The efficiency of the use of calendula on the basis of bi- oimpedance spectrometry has been determined. Comparative performance evaluation of bioimpedance due to local medical treatment of a burn with calendula officinalis at different times has been performed. Baseline characteristics of the bioimpedance of the tissues of the esophagus when the AC frequency of 50 kHz 49.4±1.43 Ohm at a fre- quency of 100 kHz — 44.1 kHz±0,96 at a frequency of 200 kHz — 41,3±1.11 Ohm. After receiving an experimental burn of the esophagus on the first day in the basic group, control group and the group without treatment the data at a frequency of 50 kHz were equal to 20.6±1,12; 20,5±1,08 and 20.4±1,01 Ohm respectively. On the third day in the basic group the data made up 22,5±0,72; 20,1±0,93; 18,6±0,87 Ohms at frequen- cies AC 50; 100; 200 kHz, respectively, and in control– 20,9±0,84; 19,2±0,75; 18,1±0,64 Om. In the group treated on the third day the bioimpedance was 17.3±1,1; 16,7±0,59 and 16.4±0,53 Ohms frequency alternating current 50, 100 and 200 kHz, re- spectively. On the 21st day of the experiment in the basic group the indicators of im- pedance equaled to 33,7±1,28; 30,8±1,26; 26,6±1,31 at frequencies of 50; 100; 200 kHz. On the 40th day bioimpedance in the main group amounted to 35,2±1,30; 31,3±1,13; 27,1±0,98 Om. Despite treatment, the impedance didn’t not reach the initial values. Thus, a pronounced antiexudative activity of calendula officinalis has been detected.

chemical burn of the esophagus; calendula officinalis; experiment; bioim- pedance; spectrometry; exudation, inflammation.